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  Bursts of openings in transmitter activated ion channels

Colquhoun, D., & Sakmann, B. (1983). Bursts of openings in transmitter activated ion channels. In B. Sakmann, & E. Neher (Eds.), Single Channel Recording (pp. 345-364). New York: Plenum Press.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-AFB6-D Version Permalink: http://hdl.handle.net/21.11116/0000-0000-D8D2-F
Genre: Book Chapter

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Sakmann_1983_Single-Channel Recording_345.pdf (Any fulltext), 3MB
 
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 Creators:
Colquhoun, David, Author
Sakmann, Bert1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: Fast Component; Closed Time; Burst Duration; Spinal Cord Neuron; Exponential Component
 Abstract: Many agonists, in particular those that are involved in neurotransmission, and their analogues, work by opening discrete pores, or ion channels, in cell membranes. For example, acetylcholine (ACh) opens cation-permeable channels coupled to nicotinic receptors at the voluntary muscle end plate. It also opens potassium-selective channels coupled to muscarinic receptors in the sinoatrial node of heart. Glycine, a putative inhibitory transmitter in the spinal cord, opens anion-permeable channels in some spinal cord neurons. The aim of the work discussed is the elucidation of mechanisms by which these agonists cause ion channels to open. First, the view derived from work in the 1970s is reviewed; then the new contributions from single-channel current recordings are presented.

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Language(s): eng - English
 Dates: 1983
 Publication Status: Published in print
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: Single Channel Recording
Source Genre: Book
 Creator(s):
Sakmann, B.1, Editor            
Neher, E., Editor
Affiliations:
1 Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701            
Publ. Info: New York : Plenum Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 345 - 364 Identifier: -