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  Complement activation correlates with liver necrosis and fibrosis in chronic hepatitis C

Vasel, M., Rutz, R., Bersch, C., Feick, P., Singer, M. V., Kirschfink, M., et al. (2014). Complement activation correlates with liver necrosis and fibrosis in chronic hepatitis C. CLINICAL IMMUNOLOGY, 150(2), 149-156. doi:10.1016/j.clim.2013.11.014.

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 Creators:
Vasel, Matthäus1, Author              
Rutz, Renate2, Author
Bersch, Claus2, Author
Feick, Peter2, Author
Singer, Manfred V.2, Author
Kirschfink, Michael2, Author
Nakchbandi, Inaam A.1, Author              
Affiliations:
1Nakchbandi, Inaam / Translational Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565162              
2external, ou_persistent22              

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Free keywords: VIRUS-INFECTION; CORE PROTEIN; ANTIBODIES; BIOMARKER; FACTOR-5; MICEComplement; Chronic hepatitis C; Inflammation; Fibrosis; Stellate cell; Fibronectin;
 Abstract: Chronic hepatitis C viral infection modulates complement. The aim of this study was to determine whether complement analysis predicts liver inflammation and fibrosis in patients with chronic hepatitis C. 50 chronic hepatitis C patients who underwent a liver biopsy were compared to 50 healthy controls and 35 patients with various liver diseases. Total plasma complement activity (CH50) in plasma was diminished in hepatitis C patients suggesting complement activation. This decrease correlated with increased necrosis (r = -0.24, p < 0.05), and patients with levels below the normal range had a higher METAVIR activity score reflecting enhanced inflammation. SC5b-9, a marker of complement activation, correlated with inflammation (r = 0.40, p < 0.05), activity (r = 0.42, p < 0.05), and fibrosis scores (r = 0.49, p < 0.05). Finally, the prevalence of C1q auto-antibodies was higher in hepatitis C patients, and their presence was associated with increased inflammation and seemed to affect fibrosis. We conclude that complement-induced liver inflammation contributes to fibrosis in patients with chronic hepatitis C. (C) 2013 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2014-02
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: CLINICAL IMMUNOLOGY
Source Genre: Journal
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Publ. Info: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA : ACADEMIC PRESS INC ELSEVIER SCIENCE
Pages: - Volume / Issue: 150 (2) Sequence Number: - Start / End Page: 149 - 156 Identifier: ISSN: 1521-6616