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  Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration

Iuso, A., Sibon, O. C. M., Gorza, M., Heim, K., Organisti, C., Meitinger, T., et al. (2014). Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration. PLOS ONE, 9(2): e89439. doi:10.1371/journal.pone.0089439.

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 Creators:
Iuso, Arcangela1, Author
Sibon, Ody C. M.1, Author
Gorza, Matteo1, Author
Heim, Katharina1, Author
Organisti, Christina2, Author              
Meitinger, Thomas1, Author
Prokisch, Holger1, Author
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1external, ou_persistent22              
2Max Planck Research Group: Sensory Neurogenetics / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: BRAIN IRON ACCUMULATION; KINASE-ASSOCIATED NEURODEGENERATION; MODEL; GENE; DEGENERATION; MUTATIONS; FEATURES; SUBTYPE
 Abstract: Mutations in the orphan gene C19orf12 were identified as a genetic cause in a subgroup of patients with NBIA, a neurodegenerative disorder characterized by deposits of iron in the basal ganglia. C19orf12 was shown to be localized in mitochondria, however, nothing is known about its activity and no functional link exists to the clinical phenotype of the patients. This situation led us to investigate the effects of C19orf12 down-regulation in the model organism Drosophila melanogaster. Two genes are present in D. melanogaster, which are orthologs of C19orf12, CG3740 and CG11671. Here we provide evidence that transgenic flies with impaired C19orf12 homologs reflect the neurodegenerative phenotype and represent a valid tool to further analyze the pathomechanism in C19orf12-associated NBIA.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Published online
 Pages: 8
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 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: PLOS ONE
Source Genre: Journal
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Publ. Info: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA : PUBLIC LIBRARY SCIENCE
Pages: - Volume / Issue: 9 (2) Sequence Number: e89439 Start / End Page: - Identifier: ISSN: 1932-6203