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  Structure of the mitochondrial translocator protein in complex with a diagnostic ligand.

Jaremko, L., Jaremko, M., Giller, K., Becker, S., & Zweckstetter, M. (2014). Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science, 343(6177), 1363-1366. doi:10.1126/science.1248725.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-F78D-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CE18-D
Genre: Journal Article

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2008012.pdf (Publisher version), 2MB
 
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 Creators:
Jaremko, L.1, Author              
Jaremko, M.1, Author              
Giller, K.1, Author              
Becker, S.1, Author              
Zweckstetter, M.2, Author              
Affiliations:
1Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              
2Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              

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 Abstract: The 18-kilodalton translocator protein TSPO is found in mitochondrial membranes and mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of TSPO in mitochondrial function, TSPO ligands are used for a variety of diagnostic and therapeutic applications in animals and humans. We present the three-dimensional high-resolution structure of mammalian TSPO reconstituted in detergent micelles in complex with its high-affinity ligand PK11195. The TSPO-PK11195 structure is described by a tight bundle of five transmembrane alpha helices that form a hydrophobic pocket accepting PK11195. Ligand-induced stabilization of the structure of TSPO suggests a molecular mechanism for the stimulation of cholesterol transport into mitochondria.

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Language(s): eng - English
 Dates: 2014-03-21
 Publication Status: Published in print
 Pages: 5
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.1248725
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 343 (6177) Sequence Number: - Start / End Page: 1363 - 1366 Identifier: -