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  Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex

Oberlaender, M., de Kock, C. P., Bruno, R. M., Ramirez, A., Meyer, H. S., Dercksen, V. J., et al. (2012). Cell type-specific three-dimensional structure of thalamocortical circuits in a column of rat vibrissal cortex. Cereb Cortex, 22(22 (10)), 2375-21391. doi:10.1093/cercor/bhr317.

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Genre: Journal Article
Alternative Title : Cereb Cortex

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 Creators:
Oberlaender, M.1, Author
de Kock, C. P. , Author
Bruno, R. M., Author
Ramirez, A., Author
Meyer, H. S.1, Author
Dercksen, V. J., Author
Helmstaedter, M.2, Author
Sakmann, B.1, Author
Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288              
2MPI of Neurobiology, Max Planck Society, Am Klopferspitz 18, 82152 Martinsried, DE, ou_1110547              

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Free keywords: Animals, Nerve Net/cytology/physiology, Rats, Rats, Wistar, Sensory Receptor Cells/classification/*cytology/*physiology, Somatosensory Cortex/*cytology/*physiology, Thalamus/*cytology/*physiology, Touch/physiology
 Abstract: Soma location, dendrite morphology, and synaptic innervation may represent key determinants of functional responses of individual neurons, such as sensory-evoked spiking. Here, we reconstruct the 3D circuits formed by thalamocortical afferents from the lemniscal pathway and excitatory neurons of an anatomically defined cortical column in rat vibrissal cortex. We objectively classify 9 cortical cell types and estimate the number and distribution of their somata, dendrites, and thalamocortical synapses. Somata and dendrites of most cell types intermingle, while thalamocortical connectivity depends strongly upon the cell type and the 3D soma location of the postsynaptic neuron. Correlating dendrite morphology and thalamocortical connectivity to functional responses revealed that the lemniscal afferents can account for some of the cell type- and location-specific subthreshold and spiking responses after passive whisker touch (e.g., in layer 4, but not for other cell types, e.g., in layer 5). Our data provides a quantitative 3D prediction of the cell type-specific lemniscal synaptic wiring diagram and elucidates structure-function relationships of this physiologically relevant pathway at single-cell resolution.

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 Dates: 2012
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Degree: -

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Title: Cereb Cortex
Source Genre: Journal
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Publ. Info: London : Oxford University Press
Pages: - Volume / Issue: 22 (22 (10)) Sequence Number: - Start / End Page: 2375 - 21391 Identifier: -