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  Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew

Van Hooser, S. D., Roy, A., Rhodes, H. J., Culp, J. H., & Fitzpatrick, D. (2013). Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew. The Journal of Neuroscience, 33(28), 11494-11505. doi:10.1523/JNEUROSCI.1464-13.2013.

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 Creators:
Van Hooser, S. D., Author
Roy, A., Author
Rhodes, H. J., Author
Culp, J. H., Author
Fitzpatrick, D.1, Author
Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288              

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Free keywords: Animals, Cats, Evoked Potentials, Visual/physiology, Female, Geniculate Bodies/*physiology, Male, Photic Stimulation/*methods, Species Specificity, Tupaiidae, Visual Cortex/*physiology, Visual Fields/*physiology
 Abstract: Tree shrew primary visual cortex (V1) exhibits a pronounced laminar segregation of inputs from different classes of relay neurons in the lateral geniculate nucleus (LGN). We examined how several receptive field (RF) properties were transformed from LGN to V1 layer 4 to V1 layer 2/3. The progression of RF properties across these stages differed markedly from that found in the cat. V1 layer 4 cells are largely similar to the the LGN cells that provide their input, being dominated by a single sign (ON or OFF) and being strongly modulated by sinusoidal gratings. Some layer 4 neurons, notably those near the edges of layer 4, exhibited increased orientation selectivity, and most layer 4 neurons exhibited a preference for lower temporal frequencies. Neurons in cortical layer 2/3 differ significantly from those in the LGN; most exhibited strong orientation tuning and both ON and OFF responses. The strength of orientation selectivity exhibited a notable sublaminar organization, with the strongest orientation tuned neurons in the most superficial parts of layer 2/3. Modulation indexes provide evidence for simple and complex cells in both layer 4 and layer 2/3. However, neurons with high modulation indexes were heterogenous in the spatial organization of ON and OFF responses, with many of them exhibiting unbalanced ON and OFF responses rather than well-segregated ON and OFF subunits. When compared to the laminar organization of V1 in other mammals, these data show that the process of natural selection can result in significantly altered structure/function relationships in homologous cortical circuits.

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 Dates: 2013
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
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Title: The Journal of Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Baltimore, MD : The Society for Neuroscience
Pages: 11 Volume / Issue: 33 (28) Sequence Number: - Start / End Page: 11494 - 11505 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187