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  Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Kolinko, I., Lohße, A., Borg, S., Raschdorf, O., Jogler, C., Tu, Q., et al. (2014). Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters. NATURE NANOTECHNOLOGY, 9(3), 193-197. doi:10.1038/NNANO.2014.13.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F45-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F47-1
Genre: Journal Article

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 Creators:
Kolinko, Isabel1, Author
Lohße, Anna1, Author
Borg, Sarah1, Author
Raschdorf, Oliver2, Author              
Jogler, Christian1, Author
Tu, Qiang1, Author
Posfai, Mihaly1, Author
Tompa, Eva1, Author
Plitzko, Jürgen M.2, Author              
Brachmann, Andreas1, Author
Wanner, Gerhard1, Author
Müller, Rolf1, Author
Zhang, Youming1, Author
Schüler, Dirk1, Author
Affiliations:
1external, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: MAGNETOSPIRILLUM-GRYPHISWALDENSE; MAGNETOTACTIC BACTERIA; BIOMINERALIZATION; PROTEIN; ISLAND; MEMBRANE; EXPRESSION; CONTRAST; REVEALS
 Abstract: The synthetic production of monodisperse single magnetic domain nanoparticles at ambient temperature is challenging(1),(2). In nature, magnetosomes-membrane- bound magnetic nanocrystals with unprecedented magnetic properties-can be biomineralized by magnetotactic bacteria(3). However, these microbes are difficult to handle. Expression of the underlying biosynthetic pathway from these fastidious microorganisms within other organisms could therefore greatly expand their nanotechnological and biomedical applications(4),(5). So far, this has been hindered by the structural and genetic complexity of the magnetosome organelle and insufficient knowledge of the biosynthetic functions involved. Here, we show that the ability to biomineralize highly ordered magnetic nanostructures can be transferred to a foreign recipient. Expression of a minimal set of genes from the magnetotactic bacterium Magnetospirillum gryphiswaldense resulted in magnetosome biosynthesis within the photosynthetic model organism Rhodospirillum rubrum. Our findings will enable the sustainable production of tailored magnetic nanostructures in biotechnologically relevant hosts and represent a step towards the endogenous magnetization of various organisms by synthetic biology.

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Language(s): eng - English
 Dates: 2014-03
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000332637200012
DOI: 10.1038/NNANO.2014.13
 Degree: -

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Title: NATURE NANOTECHNOLOGY
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 9 (3) Sequence Number: - Start / End Page: 193 - 197 Identifier: ISSN: 1748-3387