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Free keywords:
Animals
Chromatin/metabolism
*Enhancer Elements, Genetic
Humans
Promoter Regions, Genetic
RNA, Long Noncoding/*metabolism
Transcription, Genetic
*Transcriptional Activation
Abstract:
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.