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  Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice

Weidner, C., Wowro, S. J., Freiwald, A., Kodelja, V., Abdel-Aziz, H., Kelber, O., et al. (2014). Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice. Molecular nutrition & food research, 58(4), 903-907. doi:10.1002/mnfr.201300477.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F76-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F78-4
Genre: Journal Article

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Weidner.pdf (Publisher version), 207KB
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© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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 Creators:
Weidner, C.1, Author              
Wowro, S. J.1, Author              
Freiwald, A.1, Author              
Kodelja, V.2, Author              
Abdel-Aziz, H., Author
Kelber, O., Author
Sauer, S.1, Author              
Affiliations:
1Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, Ihnestr. 73, 14195 Berlin, Germany, ou_1479662              
2Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, Ihnestr, 73, 14195 Berlin, Germany, ou_1433554              

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Free keywords: Diabetes; Dyslipidemia; Functional Food; Melissa officinalis; Peroxisome proliferator-activated receptor
 Abstract: Over the last decades polyetiological metabolic diseases such as obesity and type 2 diabetes have emerged as a global epidemic. Efficient strategies for prevention and treatment include dietary intervention and the development of validated nutraceuticals. Safe extracts of edible plants provide a resource of structurally diverse molecules that can effectively interfere with multifactorial diseases. In this study, we describe the application of ethanolic lemon balm (Melissa officinalis) leaves extract for the treatment of insulin-resistance and dyslipidemia in mice. We show that lemon balm extract (LBE) activates the peroxisome proliferator-activated receptors (PPARs), which have key roles in the regulation of whole body glucose and lipid metabolism. Application of LBE (0.6 mg/mL) to human primary adipocytes resulted in specific peroxisome proliferator-activated receptor target gene expression. LBE treatment of insulin-resistant high-fat diet-fed C57BL/6 mice (200 mg/kg/day) for 6 weeks considerably reduced hyperglycemia and insulin resistance, plasma triacylglycerol, nonesterified fatty acids and LDL/VLDL cholesterol levels. Taken together, ethanolic lemon balm extract can potentially be used to prevent or concomitantly treat type 2 diabetes and associated disorders such as dyslipidemia and hypercholesterolemia.

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Language(s): eng - English
 Dates: 2013-11-242014-04
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mnfr.201300477
ISSN: 1613-4133 (Electronic)1613-4125 (Linking)
URI: http://www.ncbi.nlm.nih.gov/pubmed/24272914
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Title: Molecular nutrition & food research
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Source Genre: Journal
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Pages: - Volume / Issue: 58 (4) Sequence Number: - Start / End Page: 903 - 907 Identifier: -