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  Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family

Weidner, C., Wowro, S. J., Rousseau, M., Freiwald, A., Kodelja, V., Abdel-Aziz, H., et al. (2013). Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family. PLoS One, 8(11), e80335-e80335. doi:10.1371/journal.pone.0080335.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F62-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-0F66-C
Genre: Journal Article

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 Creators:
Weidner, C.1, Author              
Wowro, S. J.1, Author              
Rousseau, M.1, Author
Freiwald, A.1, Author              
Kodelja, V.2, Author              
Abdel-Aziz, H., Author
Kelber, O., Author
Sauer, S.1, Author              
Affiliations:
1Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479662              
2Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433554              

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 Abstract: Given the significant increases in the incidence of metabolic diseases, efficient strategies for preventing and treating of these common disorders are urgently needed. This includes the development of phytopharmaceutical products or functional foods to prevent or cure metabolic diseases. Plant extracts from edible biomaterial provide a potential resource of structurally diverse molecules that can synergistically interfere with complex disorders. In this study we describe the safe application of ethanolic chamomile (Matricaria recutita) flowers extract (CFE) for the treatment and prevention of type 2 diabetes and associated disorders. We show in vitro that this extract activates in particular nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) and its isotypes. In a cellular context, in human primary adipocytes CFE administration (300 microg/ml) led to specific expression of target genes of PPARgamma, whereas in human hepatocytes CFE-induced we detected expression changes of genes that were regulated by PPARalpha. In vivo treatment of insulin-resistant high-fat diet (HFD)-fed C57BL/6 mice with CFE (200 mg/kg/d) for 6 weeks considerably reduced insulin resistance, glucose intolerance, plasma triacylglycerol, non-esterified fatty acids (NEFA) and LDL/VLDL cholesterol. Co-feeding of lean C57BL/6 mice a HFD with 200 mg/kg/d CFE for 20 weeks showed effective prevention of fatty liver formation and hepatic inflammation, indicating additionally hepatoprotective effects of the extract. Moreover, CFE treatment did not reveal side effects, which have otherwise been associated with strong synthetic PPAR-targeting molecules, such as weight gain, liver disorders, hemodilution or bone cell turnover. Taken together, modulation of PPARs and other factors by chamomile flowers extract has the potential to prevent or treat type 2 diabetes and related disorders.

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Language(s): eng - English
 Dates: 2013-11-12
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0080335
ISSN: 1932-6203 (Electronic)
URI: http://www.ncbi.nlm.nih.gov/pubmed/24265809
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (11) Sequence Number: - Start / End Page: e80335 - e80335 Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850