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  EGF receptor family: Twisting targets for improved cancer therapies.

Burgess, A. W., Henis, Y. I., Hynes, N. E., Jovin, T., Levitzki, A., Pinkas-Kramarski, R., et al. (2014). EGF receptor family: Twisting targets for improved cancer therapies. Growth Factors, 32(2), 74-81. doi:10.3109/08977194.2014.896355.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-126A-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CBEC-F
Genre: Journal Article

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 Creators:
Burgess, A. W., Author
Henis, Y. I., Author
Hynes, N. E., Author
Jovin, T.1, Author              
Levitzki, A., Author
Pinkas-Kramarski, R., Author
Yarden, Y., Author
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              

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Free keywords: Cell surface; erbB2; erbB3; FLIM; FRET; receptor dynamics; therapeutic antibodies
 Abstract: The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor - Future Directions Conference held in Jerusalem in November 2013.

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Language(s): eng - English
 Dates: 2014-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3109/08977194.2014.896355
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Title: Growth Factors
Source Genre: Journal
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Pages: - Volume / Issue: 32 (2) Sequence Number: - Start / End Page: 74 - 81 Identifier: -