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  EGF receptor family: Twisting targets for improved cancer therapies.

Burgess, A. W., Henis, Y. I., Hynes, N. E., Jovin, T., Levitzki, A., Pinkas-Kramarski, R., et al. (2014). EGF receptor family: Twisting targets for improved cancer therapies. Growth Factors, 32(2), 74-81. doi:10.3109/08977194.2014.896355.

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Burgess, A. W., Autor
Henis, Y. I., Autor
Hynes, N. E., Autor
Jovin, T.1, Autor           
Levitzki, A., Autor
Pinkas-Kramarski, R., Autor
Yarden, Y., Autor
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              

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Schlagwörter: Cell surface; erbB2; erbB3; FLIM; FRET; receptor dynamics; therapeutic antibodies
 Zusammenfassung: The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor - Future Directions Conference held in Jerusalem in November 2013.

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Sprache(n): eng - English
 Datum: 2014-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3109/08977194.2014.896355
 Art des Abschluß: -

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Titel: Growth Factors
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 32 (2) Artikelnummer: - Start- / Endseite: 74 - 81 Identifikator: -