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  Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Heinonen, A.-M., Rahman, M., Dogbevia, G., Jakobi, H., Wölfl, S., Sprengel, R., et al. (2014). Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neuroscience, 15(1), 38-49. doi:10.1186/1471-2202-15-38.

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 Creators:
Heinonen, Ann-Marie1, Author           
Rahman, Mahbubur, Author
Dogbevia, Godwin1, Author           
Jakobi, Hannah, Author
Wölfl, Stefan, Author
Sprengel, Rolf1, Author           
Schwaninger, Markus, Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497704              

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 Abstract: Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the ‘ribosomal skip’ promoting 2A peptide-bridge.

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Language(s): eng - English
 Dates: 2013-07-182014-03-052014-03-112014-03-11
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1186/1471-2202-15-38
Other: 7980
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Title: BMC Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 15 (1) Sequence Number: - Start / End Page: 38 - 49 Identifier: ISSN: 1471-2202
CoNE: https://pure.mpg.de/cone/journals/resource/111000136905018