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  Control of cerebral size and thickness.

Tuoc, T., Pavlakis, E., Tylkowski, M. A., & Stoykova, A. (2014). Control of cerebral size and thickness. Cellular and Molecular Life Sciences, 71(17), 3199-3218. doi:10.1007/s00018-014-1590-7.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-766F-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CCE6-4
Genre: Journal Article

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2026385.pdf (Publisher version), 851KB
 
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 Creators:
Tuoc, T.C.1, Author              
Pavlakis, E.1, Author              
Tylkowski, M. A.1, Author              
Stoykova, A.1, Author              
Affiliations:
1Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              

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Free keywords: Cortex; Growth; Surface/radial expansion; Progenitor diversity; Molecular determinants; Epigenetic regulation; MicroRNA
 Abstract: The mammalian neocortex is a sheet of cells covering the cerebrum that provides the structural basis for the perception of sensory inputs, motor output responses, cognitive function, and mental capacity of primates. Recent discoveries promote the concept that increased cortical surface size and thickness in phylogenetically advanced species is a result of an increased generation of neurons, a process that underlies higher cognitive and intellectual performance in higher primates and humans. Here, we review some of the advances in the field, focusing on the diversity of neocortical progenitors in different species and the cellular mechanisms of neurogenesis. We discuss recent views on intrinsic and extrinsic molecular determinants, including the role of epigenetic chromatin modifiers and microRNA, in the control of neuronal output in developing cortex and in the establishment of normal cortical architecture.

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Language(s): eng - English
 Dates: 2014-03-122014-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00018-014-1590-7
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Title: Cellular and Molecular Life Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 71 (17) Sequence Number: - Start / End Page: 3199 - 3218 Identifier: -