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  Proteins in the gas phase.

Meyer, T., Gabelica, V., Grubmüller, H., & Orozco, M. (2013). Proteins in the gas phase. Wiley Interdisciplinary Reviews: Computational Molecular Science, 3(4), 408-425. doi:10.1002/wcms.1130.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-7893-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CDB1-E
Genre: Journal Article

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2027835.pdf (Publisher version), 636KB
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Meyer, T.1, Author              
Gabelica, V., Author
Grubmüller, H.1, Author              
Orozco, M., Author
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1Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578631              

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 Abstract: Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins have thus been carried out in aqueous environment. However, recent experimental approaches have opened the possibility to gain structural information on proteins from gas-phase measurements. The obtained results revealed significant structural memory in proteins when transferred from water to the gas phase. However, after several years of experimental and theoretical research, the nature of the structural changes induced by vaporization, the exact characteristics of proteins in the gas phase, and the physicochemical forces stabilizing dehydrated proteins are still unclear. We will review here these issues using both experimental and theoretical sources of information

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Language(s): eng - English
 Dates: 2012-11-292013-07
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/wcms.1130
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Title: Wiley Interdisciplinary Reviews: Computational Molecular Science
Source Genre: Journal
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Pages: - Volume / Issue: 3 (4) Sequence Number: - Start / End Page: 408 - 425 Identifier: -