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  Circuit mechanisms of GluA1-dependent spatial working memory

Freudenberg, F., Marx, V., Seeburg, P. H., Sprengel, R., & Celikel, T. (2013). Circuit mechanisms of GluA1-dependent spatial working memory. Hippocampus, 23(12), 1359-1366. doi:10.1002/hipo.22184.

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 Urheber:
Freudenberg, Florian1, Autor           
Marx, Verena1, Autor           
Seeburg, Peter H.1, Autor           
Sprengel, Rolf1, Autor           
Celikel, Tansu2, Autor           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Schlagwörter: Spatial working memory; GluA1; AMPA; Neural circuits; gene targeting
 Zusammenfassung: Spatial working memory (SWM), the ability to process and manipulate spatial information over a relatively short period of time, requires an intact hippocampus, but also involves other forebrain nuclei in both in rodents and humans. Previous studies in mice showed that the molecular mechanism of SWM includes activation of AMPA receptors containing the GluA1 subunit (encoded by gria1) as GluA1 deletion in the whole brain (gria1–/–) results in strong SWM deficit However, since these mice globally lack GluA1, the circuit mechanisms of GluA1 contribution to SWM remain unknown. In this study, by targeted expression of GluA1 containing AMPA receptors in the forebrain of gria1–/– mice or by removing GluA1 selectively from hippocampus of mice with ‘floxed’ GluA1 alleles (gria1fl/fl), we show that SWM requires GluA1 action in cortical circuits but is only partially dependent on GluA1-containing AMPA receptors in hippocampus. We further show that hippocampal GluA1 contribution to SWM is temporally restricted and becomes prominent at longer retention intervals (≥30 s). These findings provide a novel insight into the neural circuits required for SWM processing and argue that AMPA mediated signaling across forebrain and hippocampus differentially contribute to encoding of SWM

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 Datum: 2013-07-232013-09-102013-12-01
 Publikationsstatus: Erschienen
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hipo.22184
Anderer: 7918
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Titel: Hippocampus
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, N.Y. : Wiley-Liss, Inc.
Seiten: - Band / Heft: 23 (12) Artikelnummer: - Start- / Endseite: 1359 - 1366 Identifikator: ISSN: 1050-9631
CoNE: https://pure.mpg.de/cone/journals/resource/954925593481