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  Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice

Hasan, M. T., Hernández-González, S., Dogbevia, G., Trevino, M., Bertocchi, I., Gruart, A., et al. (2013). Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nature Communications, 4: 2258, pp. 1-9. doi:10.1038/ncomms3258.

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Hasan, Mazahir T.1, Author           
Hernández-González, Samuel, Author
Dogbevia, Godwin1, Author           
Trevino, Mario1, Author           
Bertocchi, Ilaria1, Author           
Gruart, Agnès , Author
Delgado-Garcia, José M., Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and N-methyl-D-aspartate (NMDA)-specific glutamate receptor function. To investigate whether NMDA receptor in the primary motor cortex can act as a coincidence detector for activity-dependent changes in synaptic strength and associative learning, here we generate mice with deletion of the Grin1 gene, encoding the essential NMDA receptor subunit 1 (GluN1), specifically in the primary motor cortex. The loss of NMDA receptor function impairs primary motor cortex long-term potentiation in vivo. Importantly, it impairs the synaptic efficacy between the primary somatosensory and primary motor cortices and significantly reduces classically conditioned eyeblink responses. Furthermore, compared with wild-type littermates, mice lacking NMDA receptors in the primary motor cortex show slower learning in Skinner-box tasks. Thus, primary motor cortex NMDA receptors are necessary for activity-dependent synaptic strengthening and associative learning.

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Language(s): eng - English
 Dates: 2012-12-032013-07-052013-11-272013-08-27
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ncomms3258
Other: 7925
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Pages: - Volume / Issue: 4 Sequence Number: 2258 Start / End Page: 1 - 9 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723