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  Connectomic reconstruction of the inner plexiform layer in the mouse retina

Helmstaedter, M., Briggman, K., Turaga, S. C., Jain, V., Seung, H. S., & Denk, W. (2013). Connectomic reconstruction of the inner plexiform layer in the mouse retina. Nature, 500(7461), 168-174. doi:10.1038/nature12346.

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Helmstaedter, Moritz1, Author           
Briggman, Kevin1, Author           
Turaga, Srinivas C., Author
Jain, Viren, Author
Seung, H. Sebastian , Author
Denk, Winfried1, Author           
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: Comprehensive high-resolution structural maps are central to functional exploration and understanding in biology. For the nervous system, in which high resolution and large spatial extent are both needed, such maps are scarce as they challenge data acquisition and analysis capabilities. Here we present for the mouse inner plexiform layer—the main computational neuropil region in the mammalian retina—the dense reconstruction of 950 neurons and their mutual contacts. This was achieved by applying a combination of crowd-sourced manual annotation and machine-learning-based volume segmentation to serial block-face electron microscopy data. We characterize a new type of retinal bipolar interneuron and show that we can subdivide a known type based on connectivity. Circuit motifs that emerge from our data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglion cell is motion sensitive.

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Language(s): eng - English
 Dates: 2013-01-082013-06-032013-08-072013-08-08
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nature12346
Other: 7938
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 500 (7461) Sequence Number: - Start / End Page: 168 - 174 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238