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  Functional network mirrored in the prefrontal cortex, caudate nucleus and thalamus: High resolution functional imaging and structural connectivity

Jeon, H.-A., Anwander, A., & Friederici, A. D. (2014). Functional network mirrored in the prefrontal cortex, caudate nucleus and thalamus: High resolution functional imaging and structural connectivity. The Journal of Neuroscience, 34(28), 9202-9212. doi:10.1523/JNEUROSCI.0228-14.2014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8BB9-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8186-3
Genre: Journal Article

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 Creators:
Jeon, Hyeon-Ae1, Author              
Anwander, Alfred1, Author              
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Cognitive hierarchy; Functional specificity of the cortico-subcortical loop; High-resolution fMRI and dMRI
 Abstract: Despite myriads of studies on a parallel organization of cortico-striatal-thalamo-cortical loops, direct evidence of this has been lacking for the healthy human brain. Here, we scrutinize the functional specificity of the cortico-subcortical loops depending on varying levels of cognitive hierarchy as well as their structural connectivity with high-resolution fMRI and diffusion-weighted MRI (dMRI) at 7 tesla. Three levels of cognitive hierarchy were implemented in two domains: second language and nonlanguage. In fMRI, for the higher level, activations were found in the ventroanterior portion of the prefrontal cortex (PFC), the head of the caudate nucleus (CN), and the ventral anterior nucleus (VA) in the thalamus. Conversely, for the lower level, activations were located in the posterior region of the PFC, the body of the CN, and the medial dorsal nucleus (MD) in the thalamus. This gradient pattern of activations was furthermore shown to be tenable by the parallel connectivity in dMRI tractography connecting the anterior regions of the PFC with the head of the CN and the VA in the thalamus, whereas the posterior activations of the PFC were linked to the body of the CN and the MD in the thalamus. This is the first human in vivo study combining fMRI and dMRI showing that the functional specificity is mirrored within the cortico-subcortical loop substantiated by parallel networks.

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Language(s): eng - English
 Dates: 2014-05-202014-01-142014-05-252014-07-092014-07-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.0228-14.2014
PMID: 25009254
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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 34 (28) Sequence Number: - Start / End Page: 9202 - 9212 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1