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  Getting tubulin to the tip of the cilium: One IFT train, many different tubulin cargo-binding sites?

Bhogaraju, S., Weber, K., Engel, B. D., Lechtreck, K.-F., & Lorentzen, E. (2014). Getting tubulin to the tip of the cilium: One IFT train, many different tubulin cargo-binding sites? BIOESSAYS, 36(5), 463-467. doi:10.1002/bies.201400007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8B52-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8B53-7
Genre: Journal Article

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 Creators:
Bhogaraju, Sagar1, Author              
Weber, Kristina2, Author              
Engel, Benjamin D.3, Author              
Lechtreck, Karl-Ferdinand4, Author
Lorentzen, Esben1, Author              
Affiliations:
1Lorentzen, Esben / Intraflagellar Transport, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565157              
2Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              
3Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
4external, ou_persistent22              

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Free keywords: INTRAFLAGELLAR TRANSPORT IFT; LIGHT INTERMEDIATE CHAIN; FLAGELLAR LENGTH CONTROL; CHLAMYDOMONAS-FLAGELLA; DOUBLET MICROTUBULES; CYTOPLASMIC DYNEIN; DIFFUSION BARRIER; CILIARY LENGTH; KINESIN-II; PROTEINcilia; ciliogenesis; flagella; intraflagellar transport (IFT); tubulin;
 Abstract: Cilia are microtubule-based hair-like structures that project from the surfaces of eukaryotic cells. Cilium formation relies on intraflagellar transport (IFT) to move ciliary proteins such as tubulin from the site of synthesis in the cell body to the site of function in the cilium. A large protein complex (the IFT complex) is believed to mediate interactions between cargoes and the molecular motors that walk along axonemal microtubules between the ciliary base and tip. A recent study using purified IFT complexes has identified a tubulin-binding module in the two core IFT proteins IFT74 and IFT81 that likely serves to bind and transport tubulin within cilia. Here, we calculate the amount of tubulin required to support the observed cilium assembly kinetics and explore the possibility of multiple tubulin binding sites within the IFT complex.

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Language(s): eng - English
 Dates: 2014-05
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000334047000007
DOI: 10.1002/bies.201400007
 Degree: -

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Title: BIOESSAYS
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY-BLACKWELL
Pages: - Volume / Issue: 36 (5) Sequence Number: - Start / End Page: 463 - 467 Identifier: ISSN: 0265-9247