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  Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

Harner, M. E., Unger, A.-K., Izawa, T., Walther, D. M., Oezbalci, C., Geimer, S., et al. (2014). Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. ELIFE, 3: e01684. doi:10.7554/eLife.01684.

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 Creators:
Harner, Max Emanuel1, Author           
Unger, Ann-Katrin2, Author
Izawa, Toshiaki1, Author           
Walther, Dirk M.3, Author           
Oezbalci, Cagakan2, Author
Geimer, Stefan2, Author
Reggiori, Fulvio2, Author
Bruegger, Britta2, Author
Mann, Matthias3, Author           
Westermann, Benedikt2, Author
Neupert, Walter1, Author           
Affiliations:
1Neupert, Walter / Structure and Function of Mitochondria, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565163              
2external, ou_persistent22              
3Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: DYNAMIN-RELATED GTPASE; INNER-MEMBRANE; BARTH-SYNDROME; SACCHAROMYCES-CEREVISIAE; ATP SYNTHASE; ELECTRON-MICROSCOPY; CRISTAE MORPHOLOGY; CONTACT SITE; YEAST; PROTEIN
 Abstract: Structure and function of mitochondria are intimately linked. In a search for components that participate in building the elaborate architecture of this complex organelle we have identified Aim24, an inner membrane protein. Aim24 interacts with the MICOS complex that is required for the formation of crista junctions and contact sites between inner and outer membranes. Aim24 is necessary for the integrity of the MICOS complex, for normal respiratory growth and mitochondrial ultrastructure. Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes. In addition, the level of tafazzin, a cardiolipin transacylase, is drastically reduced and the composition of cardiolipin is modified like in mutants lacking tafazzin. In conclusion, Aim24 by interacting with the MICOS complex plays a key role in mitochondrial architecture, composition and function.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Published in print
 Pages: 23
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000334351700003
DOI: 10.7554/eLife.01684
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Title: ELIFE
Source Genre: Journal
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Publ. Info: SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND : ELIFE SCIENCES PUBLICATIONS LTD
Pages: - Volume / Issue: 3 Sequence Number: e01684 Start / End Page: - Identifier: ISSN: 2050-084X