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  The integrin adhesome: from genes and proteins to human disease

Winograd-Katz, S. E., Fässler, R., Geiger, B., & Legate, K. R. (2014). The integrin adhesome: from genes and proteins to human disease. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 15(4), 273-288. doi:10.1038/nrm3769.

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 Creators:
Winograd-Katz, Sabina E.1, Author
Fässler, Reinhard2, Author              
Geiger, Benjamin1, Author
Legate, Kyle R.2, Author              
Affiliations:
1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: FOCAL ADHESION KINASE; HUMAN CHONDROSARCOMA CELLS; ALPHA 3 BETA-1-INTEGRIN; LEUKOCYTE ADHESION; LINKED KINASE; GLANZMANN THROMBASTHENIA; DILATED CARDIOMYOPATHY; CARDIAC-HYPERTROPHY; EPITHELIAL-CELLS; SEGMENTAL GLOMERULOSCLEROSIS
 Abstract: The adhesive interactions of cells with their environment through the integrin family of transmembrane receptors have key roles in regulating multiple aspects of cellular physiology, including cell proliferation, viability, differentiation and migration. Consequently, failure to establish functional cell adhesions, and thus the assembly of associated cytoplasmic scaffolding and signalling networks, can have severe pathological effects. The roles of specific constituents of integrin-mediated adhesions, which are collectively known as the 'integrin adhesome', in diverse pathological states are becoming clear. Indeed, the prominence of mutations in specific adhesome molecules in various human diseases is now appreciated, and experimental as well as in silico approaches provide insights into the molecular mechanisms underlying these pathological conditions.

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Language(s): eng - English
 Dates: 2014-04
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000333586000011
DOI: 10.1038/nrm3769
 Degree: -

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Title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Source Genre: Journal
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 15 (4) Sequence Number: - Start / End Page: 273 - 288 Identifier: ISSN: 1471-0072