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  The neuromuscular junction: Selective remodeling of synaptic regulators at the nerve/muscle interface

Witzemann, V., Chevessier, F., Pacifici, P. G., & Yampolsky, P. (2013). The neuromuscular junction: Selective remodeling of synaptic regulators at the nerve/muscle interface. Mechanisms of Development, 130(6-8), 402-411. doi:10.1016/j.mod.2012.09.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8F08-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8F09-4
Genre: Journal Article

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MechanDevelop_130_2013_402.pdf (Any fulltext), 881KB
 
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 Creators:
Witzemann, Veit1, Author              
Chevessier, Frédéric1, Author              
Pacifici, Pier Giorgio1, Author              
Yampolsky, Pessah1, Author              
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1Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society, ou_1497748              

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Free keywords: Neuromuscular junction; Development; Synapse formation; Acetylcholine receptor; Muscle specific kinase; Mouse model; Homologous recombination
 Abstract: The peripheral synapses between motoneurons and skeletal muscle fibers, the neuromuscular junctions, are ideal to investigate the general principles of synaptogenesis that depend on the interaction of activity-dependent and activity-independent signals. Much has been learned from gene “knock out” mouse models that helped to identify major synaptic regulators. The “knock out” approach, however, may not distinguish between changes arising from the disruption of molecular signaling pathways and changes caused by the absence of synaptic transmission. To circumvent these problems, postsynaptic activity was modulated in mouse models by specifically targeting endplate receptors or the activity of synaptic regulators such as MuSK. Both regulators have multiple functions and acetylcholine receptors are not just signal transducers but regulate the localization and architecture of endplates. The results show that detailed analysis of mouse models will help to understand the complexity in mechanisms that regulate synaptic remodeling

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Language(s): eng - English
 Dates: 2012-09-292013-06-01
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.mod.2012.09.004
Other: 7828
 Degree: -

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Title: Mechanisms of Development
Source Genre: Journal
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Pages: - Volume / Issue: 130 (6-8) Sequence Number: - Start / End Page: 402 - 411 Identifier: ISSN: 0925-4773
CoNE: /journals/resource/954927703126