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  Kinetics: simulation and analysis

Reinstein, J. (2013). Kinetics: simulation and analysis. In G. C. K. Roberts (Ed.), Encyclopedia of Biophysics (pp. 1213-1217). Berlin, Heidelberg: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8F1C-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8F1D-7
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Seiten aus 7917.pdf (Any fulltext), 149KB
 
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 Creators:
Reinstein, Jochen1, Author              
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1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Data simulation and analysis bridge the gap between a mechanistic or kinetic model of a certain reaction and the corresponding experimental data. Since the temporal behavior of most dynamic systems is nonlinear and highly complex, it usually cannot be deduced intuitively. Although in some cases, kinetic models can be simplistic enough to allow for some intuitive insight, in most cases, specifically with nonlinear systems, the human brain is not adapted to compute the response of kinetic systems to perturbations of any kind. These perturbations could involve rapid mixing events or changes in equilibrium by pressure and temperature changes to obtain a response that could be recorded in time. Therefore, it is important to have tools for “what if” analysis to get a prediction of the expected behavior of systems and ways to analyze data ideally without being misguided. The availability of immense computing power, even with ordinary personal computers in combination with major advances in simulation and fitting programs, allows for nearly unlimited complexity of analysis. However, it is still the quality of the data and good human sense that are crucial for scientific success. Therefore, it is still important to understand the basic principles of data analysis (of course including its limitations) and to look under the hood of the computational machines. The following sections describe in hierarchical, but also mostly functional order, the modules that are relevant for data simulation and analysis.

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Language(s): eng - English
 Dates: 2013
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: Other: 7917
DOI: 10.1007/978-3-642-16712-6_66
 Degree: -

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Title: Encyclopedia of Biophysics
Source Genre: Book
 Creator(s):
Roberts, Gordon C. K., Editor
Affiliations:
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Publ. Info: Berlin, Heidelberg : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1213 - 1217 Identifier: ISBN: 978-3-642-16711-9
ISBN: 978-3-642-16712-6