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  Balance and Stability of Synaptic Structures during Synaptic Plasticity

Meyer, D., Bonhoeffer, T., & Scheuss, V. (2014). Balance and Stability of Synaptic Structures during Synaptic Plasticity. NEURON, 82(2), 430-443. doi:10.1016/j.neuron.2014.02.031.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8C8B-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8C8C-1
Genre: Journal Article

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 Creators:
Meyer, Daniel1, Author              
Bonhoeffer, Tobias1, Author              
Scheuss, Volker1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: LONG-TERM POTENTIATION; POSTSYNAPTIC DENSITY PROTEINS; SINGLE DENDRITIC SPINES; N-CADHERIN; FUNCTIONAL PLASTICITY; MORPHOLOGICAL-CHANGES; EXCITATORY SYNAPSES; HIPPOCAMPAL SLICES; LEARNING RULES; DENTATE GYRUS
 Abstract: Subsynaptic structures such as bouton, active zone, postsynaptic density (PSD) and dendritic spine, are highly correlated in their dimensions and also correlate with synapse strength. Why this is so and how such correlations are maintained during synaptic plasticity remains poorly understood. We induced spine enlargement by two-photon glutamate uncaging and examined the relationship between spine, PSD, and bouton size by two-photon time-lapse imaging and electron microscopy. In enlarged spines the PSD-associated protein Homer1c increased rapidly, whereas the PSD protein PSD-95 increased with a delay and only in cases of persistent spine enlargement. In the case of nonpersistent spine enlargement, the PSD proteins remained unchanged or returned to their original level. The ultrastructure at persistently enlarged spines displayed matching dimensions of spine, PSD, and bouton, indicating their correlated enlargement. This supports a model in which balancing of synaptic structures is a hallmark for the stabilization of structural modifications during synaptic plasticity.

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Language(s): eng - English
 Dates: 2014
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: NEURON
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 82 (2) Sequence Number: - Start / End Page: 430 - 443 Identifier: ISSN: 0896-6273