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  Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Tóth, K., Davioud-Charvet, E., et al. (2006). Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases. Angew. Chem. Internat. Ed., 45(12), 1881-1886. doi:10.1002/anie.200502756.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8E4B-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8E4C-5
Genre: Journal Article

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AngewChemIntEd_45_2006_1881.pdf (Any fulltext), 268KB
 
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 Creators:
Urig, Sabine, Author
Fritz-Wolf, Karin1, Author              
Réau, Régis , Author
Herold-Mende, Christel, Author
Tóth, Katalin, Author
Davioud-Charvet, Elisabeth, Author
Becker, Katja, Author
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              

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Free keywords: enzyme inhibitors; gold; medicinal chemistry; platinum; structure elucidation
 Abstract: Redox-based chemotherapy: The irreversible inhibition of human glutathione reductase results in a unique S-AuI-S coordination, which was determined crystallographically. The chemotherapeutic potential of phosphine–metal complexes was probed by kinetic analysis of the fast and effective inhibition of redox enzymes as well as by DNA-interaction studies and cell-proliferation tests.

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Language(s): eng - English
 Dates: 2005-08-042006-02-222006-02-222006-03-13
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/anie.200502756
Other: 7638
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Title: Angew. Chem. Internat. Ed.
Source Genre: Journal
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Pages: - Volume / Issue: 45 (12) Sequence Number: - Start / End Page: 1881 - 1886 Identifier: -