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  Detection of human utricular otoconia degeneration in vital specimen and implications for benign paroxysmal positional vertigo

Walther, L. E., Wenzel, A., Buder, J., Bloching, M. B., Kniep, R., & Blödow, A. (2014). Detection of human utricular otoconia degeneration in vital specimen and implications for benign paroxysmal positional vertigo. European Archives of Oto-Rhino-Laryngology, 271, 3133-3138. doi:10.1007/s00405-013-2784-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-B276-B Version Permalink: http://hdl.handle.net/21.11116/0000-0000-4426-9
Genre: Journal Article

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 Creators:
Walther, Leif Erik1, Author
Wenzel, Angela1, Author
Buder, Jana2, Author              
Bloching, Marc Boris1, Author
Kniep, Rüdiger3, Author              
Blödow, Alexander1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863425              
3Rüdiger Kniep, Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863437              

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 Abstract: Otoconia are assumed to be involved in inner ear disorders such as benign paroxysmal positional vertigo (BPPV). Up to now, the distinct structure and morphology of intact and degenerate human utricular otoconia has been only poorly investigated on vital specimen. In this study, human otoconia were obtained from the utricle in five patients undergoing translabyrinthine vestibular schwannoma surgery. Specimens were examined by environmental scanning electron microscopy. Intact and degenerate otoconia as well as fracture particles of otoconia and bone were analyzed by energy dispersive X-ray microanalysis (EDX) and powder X-ray diffraction (XRD). Intact otoconia reveal a uniform size showing characteristic symmetry properties. Degenerative changes can be observed at several stages with gradual minor and major changes in their morphology including fragment formation. EDX analyses reveal the characteristic chemical composition also for otoconia remnants. XRD shows that intact and degenerate otoconia as well as remnants consist of the calcite modification. In conclusion, electron microscopy serves as a standard method for morphological investigations of otoconia. Human utricular otoconia show a uniform outer morphology corresponding to a calcite-based nanocomposite. Morphological changes provide further evidence for degeneration of utricular otoconia in humans, which might be a preconditioning factor causing BPPV. In case of uncertain origin, particles can be clearly assigned to otoconial origin using EDX and XRD analyses.

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 Dates: 2014-02-232014-02-23
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1007/s00405-013-2784-6
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Title: European Archives of Oto-Rhino-Laryngology
Source Genre: Journal
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Publ. Info: Springer Berlin Heidelberg
Pages: - Volume / Issue: 271 Sequence Number: - Start / End Page: 3133 - 3138 Identifier: CoNE: /journals/resource/0937-4477