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  Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms: A resting-state fMRI study

Schäfer, A., Quinque, E. M., Kipping, J., Arélin, K., Roggenhofer, E., Frisch, S., et al. (2014). Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms: A resting-state fMRI study. Journal of Cerebral Blood Flow and Metabolism, 34(7), 1091-1095. doi:10.1038/jcbfm.2014.70.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-B555-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-817E-E
Genre: Journal Article

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 Creators:
Schäfer, Alexander1, Author              
Quinque, Eva Maria1, Author              
Kipping, Judy1, Author              
Arélin, Katrin1, 2, 3, Author              
Roggenhofer, Elisabeth1, 3, 4, Author              
Frisch, Stefan1, 5, Author              
Villringer, Arno1, 2, 3, 6, 7, Author              
Mueller, Karsten8, Author              
Schroeter, Matthias L.1, 2, 3, 9, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Centrality; Functional connectivity; Microangiopathy; Small vessel disease
 Abstract: Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.

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Language(s): eng - English
 Dates: 2014-01-032013-05-072014-02-242014-04-302014-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: BibTex Citekey: schaefer2014early
DOI: 10.1038/jcbfm.2014.70
PMID: 24780899
Other: Epub 2014
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 34 (7) Sequence Number: - Start / End Page: 1091 - 1095 Identifier: ISSN: 0271-678X
CoNE: /journals/resource/954925503202