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  Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms: A resting-state fMRI study

Schäfer, A., Quinque, E. M., Kipping, J., Arélin, K., Roggenhofer, E., Frisch, S., et al. (2014). Early small vessel disease affects frontoparietal and cerebellar hubs in close correlation with clinical symptoms: A resting-state fMRI study. Journal of Cerebral Blood Flow and Metabolism, 34(7), 1091-1095. doi:10.1038/jcbfm.2014.70.

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Genre: Zeitschriftenartikel

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https://journals.sagepub.com/doi/10.1038/jcbfm.2014.70 (Verlagsversion)
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 Urheber:
Schäfer, Alexander1, Autor           
Quinque, Eva Maria1, Autor           
Kipping, Judy1, Autor           
Arélin, Katrin1, 2, 3, Autor           
Roggenhofer, Elisabeth1, 3, 4, Autor           
Frisch, Stefan1, 5, Autor           
Villringer, Arno1, 2, 3, 6, 7, Autor           
Mueller, Karsten8, Autor           
Schroeter, Matthias L.1, 2, 3, 9, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, Goethe University, Frankfurt, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

Inhalt

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Schlagwörter: Centrality; Functional connectivity; Microangiopathy; Small vessel disease
 Zusammenfassung: Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.

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Sprache(n): eng - English
 Datum: 2014-01-032013-05-072014-02-242014-04-302014-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: BibTex Citekey: schaefer2014early
DOI: 10.1038/jcbfm.2014.70
PMID: 24780899
Anderer: Epub 2014
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : LIFE-Leipzig Research Center for Civilization Diseases at the University of Leipzig
Projektname : -
Grant ID : -
Förderprogramm : German Consortium for Frontotemporal Lobar Degeneration
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : MaxNet Aging
Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : -
Förderprogramm : IFB-Integrated Research and Treatment Center Adiposity Diseases at the University of Leipzig
Förderorganisation : German Federal Ministry of Education and Research (BMBF)

Quelle 1

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Titel: Journal of Cerebral Blood Flow and Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 34 (7) Artikelnummer: - Start- / Endseite: 1091 - 1095 Identifikator: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202