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  Age-related differences in effective connectivity of brain regions involved in Japanese kanji processing with homophone judgment task

Wu, C.-Y., Koh, J. Y. S., Ho, M.-H.-R., Miyakoshi, M., Nakai, T., & Chen, S.-H.-A. (2014). Age-related differences in effective connectivity of brain regions involved in Japanese kanji processing with homophone judgment task. Brain and Language, 135, 32-41. doi:10.1016/j.bandl.2014.04.005.

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 Creators:
Wu, Chiao-Yi1, Author              
Koh, Jia Ying Serene1, Author
Ho, Moon-Ho Ringo1, Author
Miyakoshi, Makoto2, 3, 4, Author
Nakai, Toshiharu3, Author
Chen, Shen-Hsing Annabel1, Author
Affiliations:
1Division of Psychology, School of Humanities and Social Sciences, Nanyang Technological University, Singapore, ou_persistent22              
2Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, La Jolla, CA, USA, ou_persistent22              
3Neuroimaging and Informatics Lab, National Center for Geriatrics and Gerontology, Obu, Japan, ou_persistent22              
4Japan Society for the Promotion of Sciences, Tokyo, Japan, ou_persistent22              

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Free keywords: Functional magnetic resonance imaging (fMRI); Dynamic causal modeling (DCM); Aging; Kanji processing; Orthography; Phonology; Semantics; Effective connectivity
 Abstract: Reading is a complex process involving neural networks in which connections may be influenced by task demands and other factors. We employed functional magnetic resonance imaging and dynamic causal modeling to examine age-related influences on left-hemispheric kanji reading networks. During a homophone judgment task, activation in the middle frontal gyrus, and dorsal and ventral inferior frontal gyri were identified, representing areas involved in orthographic, phonological, and semantic processing, respectively. The young adults showed a preference for a semantically-mediated pathway from orthographic inputs to the retrieval of phonological representations, whereas the elderly preferred a direct connection from orthographic inputs to phonological lexicons prior to the activation of semantic representations. These sequential pathways are in line with the lexical semantic and non-semantic routes in the dual-route cascaded model. The shift in reading pathways accompanied by slowed reaction time for the elderly might suggest age-related declines in the efficiency of network connectivity.

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Language(s): eng - English
 Dates: 2014-04-092014-06-022014-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.bandl.2014.04.005
PMID: 24893344
Other: Epub 2014
 Degree: -

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Title: Brain and Language
Source Genre: Journal
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Pages: - Volume / Issue: 135 Sequence Number: - Start / End Page: 32 - 41 Identifier: ISSN: 0093-934X
CoNE: https://pure.mpg.de/cone/journals/resource/954922647078