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  Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults

Witte, V., Kerti, L., Margulies, D. S., & Flöel, A. (2014). Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. The Journal of Neuroscience, 34(23), 7862-7870. doi:10.1523/JNEUROSCI.0385-14.2014.

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 Creators:
Witte, Veronica1, 2, 3, Author           
Kerti, Lucia1, Author
Margulies, Daniel S.4, Author           
Flöel, Agnes1, 2, 5, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
5Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Aging; CR-mimetic; HbA1c; Microstructure; Resting-state fMRI
 Abstract: Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight older individuals that successfully completed 26 weeks of resveratrol intake (200 mg/d) were pairwise matched to 23 participants that received placebo (total n = 46, 18 females, 50–75 years). Before and after the intervention/control period, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity (FC) of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were assayed. We observed a significant effect of resveratrol on retention of words over 30 min compared with placebo (p = 0.038). In addition, resveratrol led to significant increases in hippocampal FC, decreases in glycated hemoglobin (HbA1c) and body fat, and increases in leptin compared with placebo (all p < 0.05). Increases in FC between the left posterior hippocampus and the medial prefrontal cortex correlated with increases in retention scores and with decreases in HbA1c (all p < 0.05). This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults. Our findings offer the basis for novel strategies to maintain brain health during aging.

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Language(s): eng - English
 Dates: 2014-04-162014-01-282014-04-222014-06-04
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.0385-14.2014
PMID: 24899709
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Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
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Pages: - Volume / Issue: 34 (23) Sequence Number: - Start / End Page: 7862 - 7870 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1