Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole 
Inhibitors Targeting the PDEδ Prenyl Binding Site

Zimmermann, Gunther; Schultz-Fademrecht, Carsten; Küchler, Philipp; Murarka, Sandip; Ismail, Shehab; Triola, Gemma; Nussbaumer, Peter; Wittinghofer, Alfred; Waldmann, Herbert

doi:10.1021/jm500632s

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Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site

Zimmermann, G., Schultz-Fademrecht, C., Küchler, P., Murarka, S., Ismail, S., Triola, G., et al. (2014). Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site. Journal of Medicinal Chemistry, 57(12), 5435-5448. doi:10.1021/jm500632s.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-BA15-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-DA55-8

Genre: Journal Article

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Creators:
Zimmermann, Gunther¹, Author
Schultz-Fademrecht, Carsten², Author
Küchler, Philipp¹, Author
Murarka, Sandip¹, Author
Ismail, Shehab³, Author
Triola, Gemma¹, Author
Nussbaumer, Peter², Author
Wittinghofer, Alfred³, Author
Waldmann, Herbert¹, Author

Affiliations:
1Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753290
2Lead Discovery Center, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany, ou_persistent22
3Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753294

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Language(s): eng - English

Dates: Date issued: 2014-06-26

Publication Status: Issued

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Rev. Type: Peer

Identifiers: DOI: 10.1021/jm500632s

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Title: Journal of Medicinal Chemistry

Source Genre: Journal

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Publ. Info: Washington DC : ACS Publications

Pages: - Volume / Issue: 57 (12) Sequence Number: - Start / End Page: 5435 - 5448 Identifier: ISSN: 0022-2623
CoNE: https://pure.mpg.de/cone/journals/resource/110992357271168