Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Heterozygous Ambra1 deficiency in mice: A genetic trait with autism-like behavior restricted to the female gender.

Dere, E., Dahm, L., Lu, D., Hammerschmidt, K., Ju, A., Tantra, M., et al. (2014). Heterozygous Ambra1 deficiency in mice: A genetic trait with autism-like behavior restricted to the female gender. Frontiers in Behavioral Neuroscience, 8: 181. doi:10.3389/fnbeh.2014.00181.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
2033093.pdf (Verlagsversion), 3MB
Name:
2033093.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Dere, E., Autor
Dahm, L., Autor
Lu, D., Autor
Hammerschmidt, K., Autor
Ju, A., Autor
Tantra, M., Autor
Kästner, A., Autor
Chowdhury, K.1, Autor           
Ehrenreich, H., Autor
Affiliations:
1Facility of Microarray Analyses, MPI for biophysical chemistry, Max Planck Society, ou_578589              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Ambra1; autophagy; heterozygous null mutant mice; autism composite score; social interaction; ultrasound communication; repetitive behavior; cognitive rigidity
 Zusammenfassung: Autism-spectrum disorders (ASD) are heterogeneous, highly heritable neurodevelopmental conditions affecting around 0.5% of the population across cultures, with a male/female ratio of approximately 4:1. Phenotypically, ASD are characterized by social interaction and communication deficits, restricted interests, repetitive behaviors, and reduced cognitive flexibility. Identified causes converge at the level of the synapse, ranging from mutation of synaptic genes to quantitative alterations in synaptic protein expression, e.g., through compromised transcriptional or translational control. We wondered whether reduced turnover and degradation of synapses, due to deregulated autophagy, would lead to similar pheno-typical consequences. Ambra1, strongly expressed in cortex, hippocampus, and striatum, is a positive regulator of Beclin1, a principal player in autophagosome formation. While homozygosity of the Ambra1 null mutation causes embryonic lethality, heterozygous mice with reduced Ambra1 expression are viable, reproduce normally, and lack any immediately obvious phenotype. Surprisingly, comprehensive behavioral characterization of these mice revealed an autism-like phenotype in Ambra1(+/-) females only, including compromised communication and social interactions, a tendency of enhanced stereotypies/repetitive behaviors, and impaired cognitive flexibility. Reduced ultrasound communication was found in adults as well as pups, which achieved otherwise normal neurodevelopmental milestones. These features were all absent in male Ambra1(+/-) mice. As a first hint explaining this gender difference, we found a much stronger reduction of Ambra1 protein in the cortex of Ambra1(+/-) females compared to males. To conclude, Ambra1 deficiency can induce an autism-like phenotype. The restriction to the female gender of autism-generation by a defined genetic trait is unique thus far and warrants further investigation.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2014-05-16
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.3389/fnbeh.2014.00181
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Frontiers in Behavioral Neuroscience
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 19 Band / Heft: 8 Artikelnummer: 181 Start- / Endseite: - Identifikator: -