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  miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110.

Song, R., Walentek, P., Sponer, N., Klimke, A., Lee, J. S., Dixon, G., et al. (2014). miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature, 510(7503), 115-120. doi:10.1038/nature13413.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-BBA3-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CDDC-0
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 Creators:
Song, R., Author
Walentek, P., Author
Sponer, N., Author
Klimke, A.1, Author              
Lee, J. S., Author
Dixon, G., Author
Harland, R., Author
Wan, Y., Author
Lishko, P., Author
Lize, M., Author
Kessel, M.1, Author              
He, L., Author
Affiliations:
1Research Group of Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578586              

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 Abstract: The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertility and strong respiratory dysfunction caused by defective mucociliary clearance. In both mouse and Xenopus, miR-34/449-deficient multiciliated cells (MCCs) exhibited a significant decrease in cilia length and number, due to defective basal body maturation and apical docking. The effect of miR-34/449 on ciliogenesis was mediated, at least in part, by post-transcriptional repression of Cp110, a centriolar protein suppressing cilia assembly. Consistent with this, cp110 knockdown in miR-34/449-deficient MCCs restored ciliogenesis by rescuing basal body maturation and docking. Altogether, our findings elucidate conserved cellular and molecular mechanisms through which miR-34/449 regulate motile ciliogenesis.

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Language(s): eng - English
 Dates: 2014-06-042014-06-05
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nature13413
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 510 (7503) Sequence Number: - Start / End Page: 115 - 120 Identifier: -