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  Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma.

Koch, R., Demant, M., Aung, T., Diersing, N., Cicholas, A., Chapuy, B., et al. (2014). Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma. Blood, 123(14), 2189-2198. doi:10.1182/blood-2013-08-523886.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-BD1F-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CC9C-A
Genre: Journal Article

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 Creators:
Koch, R., Author
Demant, M., Author
Aung, T., Author
Diersing, N., Author
Cicholas, A., Author
Chapuy, B., Author
Wenzel, D.1, Author              
Lahmann, M., Author
Güntsch, A., Author
Kiecke, C., Author
Becker, S., Author
Hupfeld, T., Author
Venkataramani, V., Author
Ziepert, M., Author
Opitz, L., Author
Klapper, W., Author
Trümper, L., Author
Wulf, G. G., Author
Affiliations:
1Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              

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 Abstract: Tumors are composed of phenotypically heterogeneous cell populations. The non-genomic mechanisms underlying transitions and interactions between cell populations are largely unknown. Here, we show that diffuse large B-cell lymphomas possess a self-organized infrastructure comprising side population (SP) and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt signaling. DNA methylation modulated SP-non-SP transitions and was correlated with the reciprocal expressions of Wnt signaling pathway agonist Wnt3a in SP cells and the antagonist secreted frizzled-related protein 4 in non-SP cells. Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighboring cells, thus modulating population equilibrium in the tumor.

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Language(s): eng - English
 Dates: 2014-04-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1182/blood-2013-08-523886
 Degree: -

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Title: Blood
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 123 (14) Sequence Number: - Start / End Page: 2189 - 2198 Identifier: -