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  Bällchen is required for self-renewal of germline stem cells in Drosophila melanogaster.

Herzig, B., Yakulov, T., Klinge, K., Günesdogan, U., Jäckle, H., & Herzig, A. (2014). Bällchen is required for self-renewal of germline stem cells in Drosophila melanogaster. Biology Open, 3(6), 510-521. doi:0.1242/bio.20147690.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-C269-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-6EE3-3
Genre: Journal Article

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 Creators:
Herzig, B.1, Author              
Yakulov, T.1, Author              
Klinge, K.1, Author              
Günesdogan, U., Author
Jäckle, H.1, Author              
Herzig, A.1, Author              
Affiliations:
1Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society, ou_578590              

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Free keywords: Bällchen; Drosophila; Germline stem cells
 Abstract: Self-renewing stem cells are pools of undifferentiated cells, which are maintained in cellular niche environments by distinct tissue-specific signalling pathways. In Drosophila melanogaster, female germline stem cells (GSCs) are maintained in a somatic niche of the gonads by BMP signalling. Here we report a novel function of the Drosophila kinase Ballchen (BALL), showing that its cell autonomous role is to maintain the self-renewing capacity of female GSCs independent of BMP signalling. ball mutant GSCs are eliminated from the niche and subsequently differentiate into mature eggs, indicating that BALL is largely dispensable for differentiation. Similar to female GSCs, BALL is required to maintain self-renewal of male GSCs, suggesting a tissue independent requirement of BALL for self-renewal of germline stem cells.

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Language(s): eng - English
 Dates: 2014-06-15
 Publication Status: Published online
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 0.1242/bio.20147690
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Title: Biology Open
Source Genre: Journal
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Pages: - Volume / Issue: 3 (6) Sequence Number: - Start / End Page: 510 - 521 Identifier: -