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  Identification of Protein Kinase Inhibitors with a Selective Negative Effect on the Viability of Epstein-Barr Virus Infected B Cell Lines

Mavromatidis, V., Varga, Z., Waczek, F., Örfi, Z., Örfi, L., Keri, G., et al. (2014). Identification of Protein Kinase Inhibitors with a Selective Negative Effect on the Viability of Epstein-Barr Virus Infected B Cell Lines. PLOS ONE, 9(4): e95688. doi:10.1371/journal.pone.0095688.

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Mavromatidis, Vassilis1, Author
Varga, Zoltan1, Author
Waczek, Frigyes1, Author
Örfi, Zoltán2, Author              
Örfi, Laszlo1, Author
Keri, Gyoergy1, Author
Mosialos, George1, Author
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1external, ou_persistent22              
2Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565172              

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Free keywords: CHRONIC LYMPHOCYTIC-LEUKEMIA; TYROSINE KINASE; BURKITTS-LYMPHOMA; CROSS-LINKING; ACTIVATION; LCK; 2A; EXPRESSION; SURVIVAL; LATENCY
 Abstract: Epstein-Barr virus (EBV) is a human herpesvirus, which is causally associated with the development of several B lymphocytic malignancies that include Burkitt's lymphomas, Hodgkin's disease, AIDS and posttransplant associated lymphomas. The transforming activity of EBV is orchestrated by several latent viral proteins that mimic and modulate cellular growth promoting and antiapoptotic signaling pathways, which involve among others the activity of protein kinases. In an effort to identify small molecule inhibitors of the growth of EBV-transformed B lymphocytes a library of 254 kinase inhibitors was screened. This effort identified two tyrosine kinase inhibitors and two MEK inhibitors that compromised preferentially the viability of EBV-infected human B lymphocytes. Our findings highlight the possible dependence of EBV-infected B lymphocytes on specific kinase-regulated pathways underlining the potential for the development of small molecule-based therapeutics that could target selectively EBV-associated human B lymphocyte malignancies.

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Language(s): eng - English
 Dates: 2014-04-23
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: PLOS ONE
Source Genre: Journal
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Publ. Info: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA : PUBLIC LIBRARY SCIENCE
Pages: - Volume / Issue: 9 (4) Sequence Number: e95688 Start / End Page: - Identifier: ISSN: 1932-6203