Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes

Cheng, Xu; Vellalath, Sveekumar; Goddard, Richard; List, Benjamin

doi:10.1021/ja8071034

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Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes

Cheng, X., Vellalath, S., Goddard, R., & List, B. (2008). Direct Catalytic Asymmetric Synthesis of Cyclic Aminals from Aldehydes. Journal of the American Chemical Society, 130(47), 15786-15787. doi:10.1021/ja8071034.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-D590-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-D591-A

Genre: Journal Article

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Creators:
Cheng, Xu¹, Author
Vellalath, Sveekumar¹, Author
Goddard, Richard², Author
List, Benjamin¹, Author

Affiliations:
1Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585
2Service Department Lehmann (EMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445625

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Free keywords: CHIRAL BRONSTED ACID; IMINES; ACTIVATION; DIFFERENCE

Abstract: A highly enantioselective Brønsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several antihypertensive aminal drugs including (R)-Thiabutazide

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Language(s): eng - English

Dates: Date issued: 2008-11-26

Publication Status: Issued

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Rev. Type: Peer

Identifiers: DOI: 10.1021/ja8071034

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Title: Journal of the American Chemical Society

Other : J. Am. Chem. Soc.

Abbreviation : JACS

Source Genre: Journal

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Pages: - Volume / Issue: 130 (47) Sequence Number: - Start / End Page: 15786 - 15787 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870