English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dynamics of a combined Medea-underdominant population transformation system

Gokhale, C. S., Reeves, R. G., & Reed, F. A. (2014). Dynamics of a combined Medea-underdominant population transformation system. BMC Evolutionary Biology, 14: 98. doi:10.1186/1471-2148-14-98.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-D7F8-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-DA95-0
Genre: Journal Article

Files

show Files
hide Files
:
Gokhale_2014.pdf (Publisher version), 902KB
Name:
Gokhale_2014.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Gokhale, Chaitanya S.1, Author              
Reeves, R. Guy2, Author              
Reed, Floyd A.2, Author              
Affiliations:
1Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              
2Research Group Population Genetics, Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445646              

Content

show
hide
Free keywords: dynamical systems; gene drive; genetic pest management; population transformation; population replacement
 Abstract: Background: Transgenic constructs intended to be stably established at high frequencies in wild populations have been demonstrated to “drive” from low frequencies in experimental insect populations. Linking such population transformation constructs to genes which render them unable to transmit pathogens could eventually be used to stop the spread of vector-borne diseases like malaria and dengue. Results: Generally, population transformation constructs with only a single transgenic drive mechanism have been envisioned. Using a theoretical modelling approach we describe the predicted properties of a construct combining autosomal Medea and underdominant population transformation systems. We show that when combined they can exhibit synergistic properties which in broad circumstances surpass those of the single systems. Conclusion: With combined systems, intentional population transformation and its reversal can be achieved readily. Combined constructs also enhance the capacity to geographically restrict transgenic constructs to targeted populations. It is anticipated that these properties are likely to be of particular value in attracting regulatory approval and public acceptance of this novel technology.

Details

show
hide
Language(s): eng - English
 Dates: 2013-10-072014-04-282014-05-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/1471-2148-14-98
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BMC Evolutionary Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: BioMed Central
Pages: - Volume / Issue: 14 Sequence Number: 98 Start / End Page: - Identifier: ISSN: 1471-2148
CoNE: /journals/resource/111000136905006