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  The upper respiratory tract as a microbial source for pulmonary infections in cystic fibrosis: parallels from island biogeography

Whiteson, K. L., Bailey, B., Bergkessel, M., Conrad, D., Delhaes, L., Felts, B., et al. (2014). The upper respiratory tract as a microbial source for pulmonary infections in cystic fibrosis: parallels from island biogeography. American Journal of Respiratory and Critical Care Medicine, 189(11), 1309-1315. doi:0.1164/rccm.201312-2129PP.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-D838-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-D839-9
Genre: Journal Article

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 Creators:
Whiteson, Katrine L., Author
Bailey, Barbara, Author
Bergkessel, Megan, Author
Conrad, Douglas, Author
Delhaes, Laurence, Author
Felts, Ben, Author
Harris, J. Kirk, Author
Hunter, Ryan, Author
Lim, Yan Wei, Author
Maughan, Heather, Author
Quinn, Robert, Author
Salamon, Peter, Author
Sullivan, James, Author
Wagner, Brandie D., Author
Rainey, Paul B.1, Author              
Affiliations:
1External Scientific Member Group Experimental and Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445637              

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 Abstract: A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical microbiology and could reframe the interpretation of recent studies comparing communities from lung explant samples, sputum samples, and oropharyngeal swabs. We propose an island biogeography model of the microbial communities inhabiting different niches in human airways. Island biogeography as applied to communities separated by time and space is a useful parallel for exploring microbial colonization of healthy and diseased lungs, with the potential to inform ourunderstanding ofmicrobial community dynamics and the relevance of microbes detected in different sample types. In this perspective, we focus on the intermixed microbial communities inhabiting different regions of the airways of patients with cystic fibrosis.

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Language(s): eng - English
 Dates: 2013-12-052014-04-022014-06-01
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 0.1164/rccm.201312-2129PP
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Title: American Journal of Respiratory and Critical Care Medicine
  Other : Am J Respir Crit Care Med
Source Genre: Journal
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Publ. Info: New York, NY : American Lung Association
Pages: - Volume / Issue: 189 (11) Sequence Number: - Start / End Page: 1309 - 1315 Identifier: ISSN: 1073-449X (print)
ISSN: 0003-0805 (print)
ISSN: 1535-4970 (online)
CoNE: /journals/resource/954927517549