Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb 
repression

Kalb, Reinhard; Latwiel, Sebastian; Baymaz, H. Irem; Jansen, Pascal W. T. C.; Müller, Christoph W.; Vermeulen, Michiel; Müller, Jürg

doi:10.1038/nsmb.2833

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Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

Kalb, R., Latwiel, S., Baymaz, H. I., Jansen, P. W. T. C., Müller, C. W., Vermeulen, M., et al. (2014). Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 21(6), 569-571. doi:10.1038/nsmb.2833.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-DBED-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-DBEE-8

Genre: Journal Article

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Creators:
Kalb, Reinhard¹, Author
Latwiel, Sebastian², Author
Baymaz, H. Irem², Author
Jansen, Pascal W. T. C.², Author
Müller, Christoph W.², Author
Vermeulen, Michiel², Author
Müller, Jürg¹, Author

Affiliations:
1Müller, Jürg / Chromatin Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565161
2external, ou_persistent22

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Free keywords: PRC2; COMPLEX; METHYLTRANSFERASES; UBIQUITINATION; EXPRESSION; CHROMATIN; TARGETS; JARID2

Abstract: A key step in gene repression by Polycomb is trimethylation of histone H3 K27 by PCR2 to form H3K27me3. H3K27me3 provides a binding surface for PRC1. We show that monoubiquitination of histone H2A by PRC1-type complexes to form H2Aub creates a binding site for Jarid2-Aebp2 containing PRC2 and promotes H3K27 trimethylation on H2Aub nucleosomes. Jarid2, Aebp2 and H2Aub thus constitute components of a positive feedback loop establishing H3K27me3 chromatin domains.

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Language(s): eng - English

Dates: Date issued: 2014-06

Publication Status: Issued

Pages: 3

Publishing info: -

Table of Contents: -

Rev. Type: Peer

Identifiers: ISI: 000337010500012
DOI: 10.1038/nsmb.2833

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Title: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Source Genre: Journal

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Publ. Info: 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA : NATURE PUBLISHING GROUP

Pages: - Volume / Issue: 21 (6) Sequence Number: - Start / End Page: 569 - 571 Identifier: ISSN: 1545-9993