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  A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

Heger, K., Fierens, K., Vahl, J. C., Aszodi, A., Peschke, K., Schenten, D., et al. (2014). A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo. PLOS BIOLOGY, 12(1): e1001762. doi:10.1371/journal.pbio.1001762.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-DBC6-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-DBC7-D
Genre: Journal Article

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 Creators:
Heger, Klaus1, Author              
Fierens, Kaat2, Author
Vahl, J. Christoph1, Author              
Aszodi, Attila2, Author
Peschke, Katrin2, Author
Schenten, Dominik2, Author
Hammad, Hamida2, Author
Beyaert, Rudi2, Author
Saur, Dieter2, Author
van Loo, Geert2, Author
Roers, Axel2, Author
Lambrecht, Bart N.2, Author
Kool, Mirjam2, Author
Schmidt-Supprian, Marc1, Author              
Affiliations:
1Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565167              
2external, ou_persistent22              

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Free keywords: HOUSE-DUST MITE; CYTOKINE PRODUCTION; DENDRITIC CELLS; INDUCED ARTHRITIS; ASTHMA MODEL; A20; INTERLEUKIN-33; IL-33; MICE; AUTOIMMUNITY
 Abstract: Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-kappa B negative feedback regulator A20. While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflammatory responses downstream of IgE/Fc epsilon RI, TLRs, IL-1R, and IL-33R. As a consequence house dust mite- and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced arthritis were aggravated, in contrast to experimental autoimmune encephalomyelitis and immediate anaphylaxis. Our results provide in vivo evidence that hyperactive mast cells can exacerbate inflammatory disorders and define diseases that might benefit from therapeutic intervention with mast cell function.

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Language(s): eng - English
 Dates: 2014-01
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: PLOS BIOLOGY
Source Genre: Journal
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Publ. Info: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA : PUBLIC LIBRARY SCIENCE
Pages: - Volume / Issue: 12 (1) Sequence Number: e1001762 Start / End Page: - Identifier: ISSN: 1545-7885