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  Deficient approaches to human neuroimaging

Stelzer, J., Lohmann, G., Mueller, K., Buschmann, T., & Turner, R. (2014). Deficient approaches to human neuroimaging. Frontiers in Human Neuroscience, 8: 462. doi:10.3389/fnhum.2014.00462.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-EB30-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F08-7
Genre: Journal Article

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 Creators:
Stelzer, Johannes1, 2, Author              
Lohmann, Gabriele3, 4, Author              
Mueller, Karsten5, Author              
Buschmann, Tilo1, 6, Author              
Turner, Robert1, 7, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
3Department of Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, ou_persistent22              
4Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497796              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Department of Diagnotics, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
7Department of Physics, University of Nottingham, United Kingdom, ou_persistent22              

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Free keywords: fMRI; Cognitive neuroscience; Brain mapping; Functional localization; Critical neuroscience
 Abstract: Functional magnetic resonance imaging (fMRI) is the workhorse of imaging-based human cognitive neuroscience. The use of fMRI is ever-increasing; within the last 4 years more fMRI studies have been published than in the previous 17 years.This large body of research has mainly focused on the functional localization of condition- or stimulus-dependent changes in the blood-oxygenation-level dependent signal. In recent years, h owever, many aspects of the commonly practiced analysis frameworks and methodologies have been critically reassessed. Here we summarize these critiques, providing an overview of the major conceptual and practical deficiencies in widely used brain-mapping approaches, and exemplifysomeoftheseissuesbytheuseofimagingdataandsimulations. Inparticular, we discuss the inherent pitfalls and shortcomings of methodologies for statistical parametric mapping. Our critique emphasizes recent reports of excessively high numbers of both false positive and false negative findings in fMRI brain mapping. We outline our view regarding the broader scientific implications of these methodological considerations and briefly discuss possible solutions.

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Language(s): eng - English
 Dates: 2014-03-122014-06-062014-07-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2014.00462
PMID: 25071503
PMC: PMC4076796
Other: eCollection 2014
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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 8 Sequence Number: 462 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: /journals/resource/1662-5161