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  Common molecular basis of the sentence comprehension network revealed by neurotransmitter receptor fingerprints

Zilles, K., Bacha-Trams, M., Palomero-Gallagher, N., Amunts, K., & Friederici, A. D. (2015). Common molecular basis of the sentence comprehension network revealed by neurotransmitter receptor fingerprints. Cortex, 63, 79-89. doi:10.1016/j.cortex.2014.07.007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-F4D2-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-5530-7
Genre: Journal Article

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 Creators:
Zilles, Karl1, 2, Author
Bacha-Trams, Mareike1, 3, Author              
Palomero-Gallagher, Nicola1, Author
Amunts, Katrin1, 4, Author
Friederici, Angela D.3, Author              
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
4C. and O. Vogt Institute for Brain Research, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              

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Free keywords: Language; Transmitter receptors; Brain mapping; Human cerebral cortex
 Abstract: The language network is a well-defined large-scale neural network of anatomically and functionally interacting cortical areas. The successful language process requires the transmission of information between these areas. Since neurotransmitter receptors are key molecules of information processing, we hypothesized that cortical areas which are part of the same functional language network may show highly similar multireceptor expression pattern (“receptor fingerprint”), whereas those that are not part of this network should have different fingerprints. Here we demonstrate that the relation between the densities of 15 different excitatory, inhibitory and modulatory receptors in eight language-related areas are highly similar and differ considerably from those of 18 other brain regions not directly involved in language processing. Thus, the fingerprints of all cortical areas underlying a large-scale cognitive domain such as language is a characteristic, functionally relevant feature of this network and an important prerequisite for the underlying neuronal processes of language functions.

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Language(s): eng - English
 Dates: 2014-02-132014-07-102014-08-122015-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cortex.2014.07.007
PMID: 25243991
PMC: PMC4317196
Other: Epub 2014
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Title: Cortex
  Other : Cortex
Source Genre: Journal
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Pages: - Volume / Issue: 63 Sequence Number: - Start / End Page: 79 - 89 Identifier: ISSN: 0010-9452
CoNE: /journals/resource/954925393344