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  DNA damage Mechanisms and principles of homology search during recombination

Renkawitz, J., Lademann, C. A., & Jentsch, S. (2014). DNA damage Mechanisms and principles of homology search during recombination. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 15(6), 369-383. doi:10.1038/nrm3805.

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 Creators:
Renkawitz, Jörg1, Author              
Lademann, Claudio A.1, Author              
Jentsch, Stefan1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565156              

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Free keywords: DOUBLE-STRAND-BREAK; SISTER-CHROMATID COHESION; RECURRENT CHROMOSOMAL TRANSLOCATIONS; YEAST SACCHAROMYCES-CEREVISIAE; COLI RECA PROTEIN; D-LOOP FORMATION; NUCLEAR-ORGANIZATION; ESCHERICHIA-COLI; MITOTIC RECOMBINATION; RAD51 RECOMBINASE
 Abstract: Homologous recombination is crucial for genome stability and for genetic exchange. Although our knowledge of the principle steps in recombination and its machinery is well advanced, homology search, the critical step of exploring the genome for homologous sequences to enable recombination, has remained mostly enigmatic. However, recent methodological advances have provided considerable new insights into this fundamental step in recombination that can be integrated into a mechanistic model. These advances emphasize the importance of genomic proximity and nuclear organization for homology search and the critical role of homology search mediators in this process. They also aid our understanding of how homology search might lead to unwanted and potentially disease-promoting recombination events.

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Language(s): eng - English
 Dates: 2014-06
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000337245500009
DOI: 10.1038/nrm3805
 Degree: -

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Title: NATURE REVIEWS MOLECULAR CELL BIOLOGY
Source Genre: Journal
 Creator(s):
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Publ. Info: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 15 (6) Sequence Number: - Start / End Page: 369 - 383 Identifier: ISSN: 1471-0072