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  Modulating brain mechanisms resolving lexico-semantic interference during word production: A transcranial direct current stimulation study

Henseler, I., Mädebach, A., Kotz, S. A., & Jescheniak, J. D. (2014). Modulating brain mechanisms resolving lexico-semantic interference during word production: A transcranial direct current stimulation study. Journal of Cognitive Neuroscience, 26(7), 1403-1417. doi:10.1162/jocn_a_00572.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-25BB-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-82A1-3
Genre: Journal Article

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 Creators:
Henseler, Ilona1, Author              
Mädebach, Andreas2, Author
Kotz, Sonja A.3, 4, Author              
Jescheniak, Jörg D.4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2University of Leipzig, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4University of Manchester, United Kingdom, ou_persistent22              

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 Abstract: The aim of the current study was to shed further light on control processes that shape semantic access and selection during speech production. These processes have been linked to differential cortical activation in the left inferior frontal gyrus (IFG) and the left middle temporal gyrus (MTG); however, the particular function of these regions is not yet completely elucidated. We applied transcranial direct current stimulation to the left IFG and the left MTG (or sham stimulation) while participants named pictures in the presence of associatively related, categorically related, or unrelated distractor words. This direct modulation of target regions can help to better delineate the functional role of these regions in lexico-semantic selection. Independent of stimulation, the data show interference (i.e., longer naming latencies) with categorically related distractors and facilitation (i.e., shorter naming latencies) with associatively related distractors. Importantly, stimulation location interacted with the associative effect. Whereas the semantic interference effect did not differ between IFG, MTG, and sham stimulations, the associative facilitation effect was diminished under MTG stimulation. Analyses of latency distributions suggest this pattern to result from a response reversal. Associative facilitation occurred for faster responses, whereas associative interference resulted in slower responses under MTG stimulation. This reduction of the associative facilitation effect under transcranial direct current stimulation may be caused by an unspecific overactivation in the lexicon or by promoting competition among associatively related representations. Taken together, the results suggest that the MTG is especially involved in the processes underlying associative facilitation and that semantic interference and associative facilitation are linked to differential activation in the brain.

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Language(s): eng - English
 Dates: 2014-05-292014-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1162/jocn_a_00572
PMID: 24405107
Other: Epub 2014
 Degree: -

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Title: Journal of Cognitive Neuroscience
Source Genre: Journal
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Publ. Info: Cambridge, MA : MIT Press Journals
Pages: - Volume / Issue: 26 (7) Sequence Number: - Start / End Page: 1403 - 1417 Identifier: ISSN: 0898-929X
CoNE: /journals/resource/991042752752726