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  Functional analysis of ultra high information rates conveyed by rat vibrissal primary afferents

Chagas, A., Theis, L., Sengupta, B., Stüttgen, M., Bethge, M., & Schwarz, C. (2013). Functional analysis of ultra high information rates conveyed by rat vibrissal primary afferents. Frontiers in Neural Circuits, 7: 190, pp. 1-17. doi:10.3389/fncir.2013.00190.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-123B-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-93CB-4
Genre: Journal Article

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Chagas, AM, Author
Theis, L, Author              
Sengupta, B, Author              
Stüttgen, MC, Author
Bethge, Matthias1, 2, Author              
Schwarz, C, Author
Affiliations:
1Research Group Computational Vision and Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497805              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Sensory receptors determine the type and the quantity of information available for perception. Here, we quantified and characterized the information transferred by primary afferents in the rat whisker system using neural system identification. Quantification of “how much” information is conveyed by primary afferents, using the direct method (DM), a classical information theoretic tool, revealed that primary afferents transfer huge amounts of information (up to 529 bits/s). Information theoretic analysis of instantaneous spike-triggered kinematic stimulus features was used to gain functional insight on “what” is coded by primary afferents. Amongst the kinematic variables tested—position, velocity, and acceleration—primary afferent spikes encoded velocity best. The other two variables contributed to information transfer, but only if combined with velocity. We further revealed three additional characteristics that play a role in information transfer by primary afferents. Firstly, primary afferent spikes show preference for well separated multiple stimuli (i.e., well separated sets of combinations of the three instantaneous kinematic variables). Secondly, neurons are sensitive to short strips of the stimulus trajectory (up to 10 ms pre-spike time), and thirdly, they show spike patterns (precise doublet and triplet spiking). In order to deal with these complexities, we used a flexible probabilistic neuron model fitting mixtures of Gaussians to the spike triggered stimulus distributions, which quantitatively captured the contribution of the mentioned features and allowed us to achieve a full functional analysis of the total information rate indicated by the DM. We found that instantaneous position, velocity, and acceleration explained about 50 of the total information rate. Adding a 10 ms pre-spike interval of stimulus trajectory achieved 80–90. The final 10–20 were found to be due to non-linear coding by spike bursts.

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 Dates: 2013-12
 Publication Status: Published online
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 Identifiers: DOI: 10.3389/fncir.2013.00190
BibTex Citekey: ChagasTSSBS2013
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Title: Frontiers in Neural Circuits
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 7 Sequence Number: 190 Start / End Page: 1 - 17 Identifier: ISSN: 1662-5110
CoNE: /journals/resource/1662-5110