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  Temporal Jitter of the BOLD Signal Reveals a Reliable Initial Dip and Improved Spatial Resolution

Watanabe, M., Bartels, A., Macke, J., Murayama, Y., & Logothetis, N. (2013). Temporal Jitter of the BOLD Signal Reveals a Reliable Initial Dip and Improved Spatial Resolution. Current Biology, 23(21), 2146-2150. doi:10.1016/j.cub.2013.08.057.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-12C9-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1605-1
Genre: Journal Article

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Watanabe, M1, 2, Author              
Bartels, A1, 2, Author              
Macke, JH2, 3, Author              
Murayama, Y1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group Computational Vision and Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497805              

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 Abstract: fMRI, one of the most important noninvasive brain imaging methods, relies on the blood oxygen level-dependent (BOLD) signal, whose precise underpinnings are still not fully understood [1]. It is a widespread assumption that the components of the hemodynamic response function (HRF) are fixed relative to each other in time, leading most studies as well as analysis tools to focus on trial-averaged responses, thus using or estimating a condition- or location-specific “canonical HRF” [2, 3 and 4]. In the current study, we examined the nature of the variability of the BOLD response and asked in particular whether the positive BOLD peak is subject to trial-to-trial temporal jitter. Our results show that the positive peak of the stimulus-evoked BOLD signal exhibits a trial-to-trial temporal jitter on the order of seconds. Moreover, the trial-to-trial variability can be exploited to uncover the initial dip in the majority of voxels by pooling trial responses with large peak latencies. Initial dips exposed by this procedure possess higher spatial resolution compared to the positive BOLD signal in the human visual cortex. These findings allow for the reliable observation of fMRI signals that are physiologically closer to neural activity, leading to improvements in both temporal and spatial resolution.

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 Dates: 2013-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.cub.2013.08.057
BibTex Citekey: WatanabeBMML2013
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Title: Current Biology
Source Genre: Journal
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Pages: - Volume / Issue: 23 (21) Sequence Number: - Start / End Page: 2146 - 2150 Identifier: -