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  Visual cortex organisation in a macaque monkey with macular degeneration

Shao, Y., Keliris, G., Papanikolaou, A., Fischer, M., Zobor, D., Jägle, H., et al. (2013). Visual cortex organisation in a macaque monkey with macular degeneration. European Journal of Neuroscience, 38(10), 3456-3464. doi:10.1111/ejn.12349.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-12D2-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3D98-0
Genre: Journal Article

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Shao, Y1, 2, Author              
Keliris, GA1, 2, Author              
Papanikolaou, A1, 2, Author              
Fischer, MD, Author
Zobor, D, Author
Jägle, H, Author
Logothetis, Nikos K1, 2, Author              
Smirnakis, SM, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The visual field is retinotopically represented in early visual areas. It has been suggested that when adult primary visual cortex (V1) is deprived of normal retinal input it is capable of large-scale reorganisation, with neurons inside the lesion projection zone (LPZ) being visually driven by inputs from intact retinal regions. Early functional magnetic resonance imaging (fMRI) studies in humans with macular degeneration (MD) report > 1 cm spread of activity inside the LPZ border, whereas recent results report no shift of the LPZ border. Here, we used fMRI population receptive field measurements to study, for the first time, the visual cortex organisation of one macaque monkey with MD and to compare it with normal controls. Our results showed that the border of the V1 LPZ remained stable, suggesting that the deafferented area V1 zone of the MD animal has limited capacity for reorganisation. Interestingly, the pRF size of non-deafferented V1 voxels increased slightly (~20 on average), although this effect appears weaker than that in previous single-unit recording reports. Area V2 also showed limited reorganisation. Remarkably, area V5/MT of the MD animal showed extensive activation compared to controls stimulated over the part of the visual field that was spared in the MD animal. Furthermore, population receptive field size distributions differed markedly in area V5/MT of the MD animal. Taken together, these results suggest that V5/MT has a higher potential for reorganisation after MD than earlier visual cortex.

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 Dates: 2013-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/ejn.12349
BibTex Citekey: ShaoKPFZ2013
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Title: European Journal of Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 38 (10) Sequence Number: - Start / End Page: 3456 - 3464 Identifier: -