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  Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections

Gambino, G., Engelmann, J., Tei, L., Botta, M., Logothetis, N. K., & Mamedov, I. (2013). Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections. Biomaterials, 34(29), 7135-7142. doi:10.1016/j.biomaterials.2013.05.064.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-133F-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3DD7-9
Genre: Journal Article

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 Creators:
Gambino, Giuseppe, Author              
Engelmann, J1, 2, Author              
Tei, L, Author
Botta, M, Author
Logothetis, Nikos K2, 3, Author              
Mamedov, I2, 3, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: We developed and examined the applicability of two multimodal paramagnetic contrast agents for the longitudinal in vivo investigations of the brain projections. The classical dextran based neuroanatomical tracer was conjugated with mono- and bimetal Gd3+ complexes and an optical reporter. Relaxometric studies of both tracer molecules were performed in vitro followed by in cellulo MR and microscopy investigations. Finally, tracers were injected into the motor cortex of the rat brain; uptake and transporting properties were compared by MRI. The advantage of the multimodal approach was taken and histological studies were performed on the same animals. The histology results confirm the MRI studies demonstrating that the applied tracers labelled anterogradely the regions known for their connections with the motor cortex of the rat brain. (C) 2013 Elsevier Ltd. All rights reserved.

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 Dates: 2013-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.biomaterials.2013.05.064
BibTex Citekey: GambinoETBLM2013
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Title: Biomaterials
Source Genre: Journal
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Pages: - Volume / Issue: 34 (29) Sequence Number: - Start / End Page: 7135 - 7142 Identifier: -