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  Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes

Placidi, M., Botta, M., Kálmán, F., Hagberg, G., Baranyai, Z., Krenzer, A., et al. (2013). Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes. Chemistry - A European Journal, 19(35), 11644-11660. doi:10.1002/chem.201300763.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-1357-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3DEB-3
Genre: Journal Article

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 Creators:
Placidi, MP1, 2, Author              
Botta, M, Author
Kálmán, FK, Author
Hagberg, Gisela1, 2, Author              
Baranyai, Z, Author
Krenzer, A, Author
Rogerson, AK, Author
Tóth, I, Author
Logothetis, Nikos K1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A series of low molecular weight lanthanide complexes were developed that have high 1H longitudinal relaxivities (r1) and the potential to be used as dual frequency 1H and 19F MR probes. Their behavior was investigated in more detail through relaxometry, pH-potentiometry, luminescence, and multinuclear NMR spectroscopy. Fitting of the 1H NMRD and 17O NMR profiles demonstrated a very short water residence lifetime (<10 ns) and an appreciable second sphere effect. At lower field strengths (20 MHz), two of the complexes displayed a peak in r1 (21.7 and 16.3 mM−1 s−1) caused by an agglomeration, that can be disrupted through the addition of phosphate anions. NMR spectroscopy revealed that at least two species are present in solution interconverting through an intramolecular binding process. Two complexes provided a suitable signal in 19F NMR spectroscopy and through the selection of optimized imaging parameters, phantom images were obtained in a MRI scanner at concentrations as low as 1 mM. The developed probes could be visualized through both 1H and 19F MRI, showing their capability to function as dual frequency MRI contrast agents.

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 Dates: 2013-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/chem.201300763
BibTex Citekey: PlacidiBKHBKRTLA2013
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Title: Chemistry - A European Journal
Source Genre: Journal
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Pages: - Volume / Issue: 19 (35) Sequence Number: - Start / End Page: 11644 - 11660 Identifier: -