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  Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

Sim, N., Gottschalk, S., Pal, R., Engelmann, J., Parker, D., & Mishra, A. (2013). Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy. Chemical Science, 4(8), 3148-3153. doi:10.1039/C3SC50903F.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-001A-136B-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3EC0-1
Genre: Journal Article

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 Creators:
Sim, N, Author
Gottschalk, S1, 2, Author              
Pal, R, Author
Engelmann, J1, 2, Author              
Parker, D, Author
Mishra, A, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176 enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.

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 Dates: 2013-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/C3SC50903F
BibTex Citekey: SimGPEPM2014
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Title: Chemical Science
Source Genre: Journal
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Pages: - Volume / Issue: 4 (8) Sequence Number: - Start / End Page: 3148 - 3153 Identifier: -